diff --git a/src/event/ngx_event_openssl.h b/src/event/ngx_event_openssl.h
index 0c9e9e84012..861d3bfd0fa 100644
--- a/src/event/ngx_event_openssl.h
+++ b/src/event/ngx_event_openssl.h
@@ -27,7 +27,7 @@
 #endif
 #include <openssl/evp.h>
 #if (NGX_QUIC)
-#ifdef OPENSSL_IS_BORINGSSL
+#if (defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
 #include <openssl/hkdf.h>
 #include <openssl/chacha.h>
 #else
diff --git a/src/event/quic/ngx_event_quic.h b/src/event/quic/ngx_event_quic.h
index bab085f4626..4f899ec0a58 100644
--- a/src/event/quic/ngx_event_quic.h
+++ b/src/event/quic/ngx_event_quic.h
@@ -18,7 +18,8 @@
 #elif (defined SSL_R_MISSING_QUIC_TRANSPORT_PARAMETERS_EXTENSION)
 #define NGX_QUIC_QUICTLS_API                 1
 
-#elif (defined OPENSSL_IS_BORINGSSL || defined LIBRESSL_VERSION_NUMBER)
+#elif (defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC               \
+       || defined LIBRESSL_VERSION_NUMBER)
 #define NGX_QUIC_BORINGSSL_API               1
 
 #else
diff --git a/src/event/quic/ngx_event_quic_protection.c b/src/event/quic/ngx_event_quic_protection.c
index 885843d72d8..fdc4760e66d 100644
--- a/src/event/quic/ngx_event_quic_protection.c
+++ b/src/event/quic/ngx_event_quic_protection.c
@@ -33,7 +33,7 @@ static uint64_t ngx_quic_parse_pn(u_char **pos, ngx_int_t len, u_char *mask,
 
 static ngx_int_t ngx_quic_crypto_open(ngx_quic_secret_t *s, ngx_str_t *out,
     const u_char *nonce, ngx_str_t *in, ngx_str_t *ad, ngx_log_t *log);
-#ifndef OPENSSL_IS_BORINGSSL
+#if !(defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
 static ngx_int_t ngx_quic_crypto_common(ngx_quic_secret_t *s, ngx_str_t *out,
     const u_char *nonce, ngx_str_t *in, ngx_str_t *ad, ngx_log_t *log);
 #endif
@@ -58,7 +58,7 @@ ngx_quic_ciphers(ngx_uint_t id, ngx_quic_ciphers_t *ciphers)
     switch (id) {
 
     case TLS1_3_CK_AES_128_GCM_SHA256:
-#ifdef OPENSSL_IS_BORINGSSL
+#if (defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
         ciphers->c = EVP_aead_aes_128_gcm();
 #else
         ciphers->c = EVP_aes_128_gcm();
@@ -69,7 +69,7 @@ ngx_quic_ciphers(ngx_uint_t id, ngx_quic_ciphers_t *ciphers)
         break;
 
     case TLS1_3_CK_AES_256_GCM_SHA384:
-#ifdef OPENSSL_IS_BORINGSSL
+#if (defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
         ciphers->c = EVP_aead_aes_256_gcm();
 #else
         ciphers->c = EVP_aes_256_gcm();
@@ -80,12 +80,12 @@ ngx_quic_ciphers(ngx_uint_t id, ngx_quic_ciphers_t *ciphers)
         break;
 
     case TLS1_3_CK_CHACHA20_POLY1305_SHA256:
-#ifdef OPENSSL_IS_BORINGSSL
+#if (defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
         ciphers->c = EVP_aead_chacha20_poly1305();
 #else
         ciphers->c = EVP_chacha20_poly1305();
 #endif
-#ifdef OPENSSL_IS_BORINGSSL
+#if (defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
         ciphers->hp = (const EVP_CIPHER *) EVP_aead_chacha20_poly1305();
 #else
         ciphers->hp = EVP_chacha20();
@@ -94,7 +94,7 @@ ngx_quic_ciphers(ngx_uint_t id, ngx_quic_ciphers_t *ciphers)
         len = 32;
         break;
 
-#ifndef OPENSSL_IS_BORINGSSL
+#if !(defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
     case TLS1_3_CK_AES_128_CCM_SHA256:
         ciphers->c = EVP_aes_128_ccm();
         ciphers->hp = EVP_aes_128_ctr();
@@ -388,7 +388,7 @@ ngx_quic_crypto_init(const ngx_quic_cipher_t *cipher, ngx_quic_secret_t *s,
     ngx_quic_md_t *key, ngx_int_t enc, ngx_log_t *log)
 {
 
-#ifdef OPENSSL_IS_BORINGSSL
+#if (defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
     EVP_AEAD_CTX  *ctx;
 
     ctx = EVP_AEAD_CTX_new(cipher, key->data, key->len,
@@ -448,7 +448,7 @@ static ngx_int_t
 ngx_quic_crypto_open(ngx_quic_secret_t *s, ngx_str_t *out, const u_char *nonce,
     ngx_str_t *in, ngx_str_t *ad, ngx_log_t *log)
 {
-#ifdef OPENSSL_IS_BORINGSSL
+#if (defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
     if (EVP_AEAD_CTX_open(s->ctx, out->data, &out->len, out->len, nonce,
                           s->iv.len, in->data, in->len, ad->data, ad->len)
         != 1)
@@ -468,7 +468,7 @@ ngx_int_t
 ngx_quic_crypto_seal(ngx_quic_secret_t *s, ngx_str_t *out, const u_char *nonce,
     ngx_str_t *in, ngx_str_t *ad, ngx_log_t *log)
 {
-#ifdef OPENSSL_IS_BORINGSSL
+#if (defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
     if (EVP_AEAD_CTX_seal(s->ctx, out->data, &out->len, out->len, nonce,
                           s->iv.len, in->data, in->len, ad->data, ad->len)
         != 1)
@@ -484,7 +484,7 @@ ngx_quic_crypto_seal(ngx_quic_secret_t *s, ngx_str_t *out, const u_char *nonce,
 }
 
 
-#ifndef OPENSSL_IS_BORINGSSL
+#if !(defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
 
 static ngx_int_t
 ngx_quic_crypto_common(ngx_quic_secret_t *s, ngx_str_t *out,
@@ -563,7 +563,7 @@ void
 ngx_quic_crypto_cleanup(ngx_quic_secret_t *s)
 {
     if (s->ctx) {
-#ifdef OPENSSL_IS_BORINGSSL
+#if (defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
         EVP_AEAD_CTX_free(s->ctx);
 #else
         EVP_CIPHER_CTX_free(s->ctx);
@@ -579,7 +579,7 @@ ngx_quic_crypto_hp_init(const EVP_CIPHER *cipher, ngx_quic_secret_t *s,
 {
     EVP_CIPHER_CTX  *ctx;
 
-#ifdef OPENSSL_IS_BORINGSSL
+#if (defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
     if (cipher == (EVP_CIPHER *) EVP_aead_chacha20_poly1305()) {
         /* no EVP interface */
         s->hp_ctx = NULL;
@@ -615,7 +615,7 @@ ngx_quic_crypto_hp(ngx_quic_secret_t *s, u_char *out, u_char *in,
 
     ctx = s->hp_ctx;
 
-#ifdef OPENSSL_IS_BORINGSSL
+#if (defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
     uint32_t         cnt;
 
     if (ctx == NULL) {
diff --git a/src/event/quic/ngx_event_quic_protection.h b/src/event/quic/ngx_event_quic_protection.h
index fddc6083a32..e8eb19f9e0c 100644
--- a/src/event/quic/ngx_event_quic_protection.h
+++ b/src/event/quic/ngx_event_quic_protection.h
@@ -22,7 +22,7 @@
 #define NGX_QUIC_MAX_MD_SIZE          48
 
 
-#ifdef OPENSSL_IS_BORINGSSL
+#if (defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
 #define ngx_quic_cipher_t             EVP_AEAD
 #define ngx_quic_crypto_ctx_t         EVP_AEAD_CTX
 #else
diff --git a/src/event/quic/ngx_event_quic_ssl.c b/src/event/quic/ngx_event_quic_ssl.c
index e961c80cd60..61bae5a281a 100644
--- a/src/event/quic/ngx_event_quic_ssl.c
+++ b/src/event/quic/ngx_event_quic_ssl.c
@@ -968,7 +968,7 @@ ngx_quic_init_connection(ngx_connection_t *c)
     }
 #endif
 
-#ifdef OPENSSL_IS_BORINGSSL
+#if (defined OPENSSL_IS_BORINGSSL || defined OPENSSL_IS_AWSLC)
     if (SSL_set_quic_early_data_context(ssl_conn, p, clen) == 0) {
         ngx_ssl_error(NGX_LOG_ALERT, c->log, 0,
                       "quic SSL_set_quic_early_data_context() failed");
diff --git a/src/http/ngx_http_request.c b/src/http/ngx_http_request.c
index ceac8d307ef..c1ea40f7f7d 100644
--- a/src/http/ngx_http_request.c
+++ b/src/http/ngx_http_request.c
@@ -935,7 +935,8 @@ ngx_http_ssl_servername(ngx_ssl_conn_t *ssl_conn, int *ad, void *arg)
     sscf = ngx_http_get_module_srv_conf(cscf->ctx, ngx_http_ssl_module);
 
 #if (defined TLS1_3_VERSION                                                   \
-     && !defined LIBRESSL_VERSION_NUMBER && !defined OPENSSL_IS_BORINGSSL)
+     && !defined LIBRESSL_VERSION_NUMBER && !defined OPENSSL_IS_BORINGSSL     \
+     && !defined OPENSSL_IS_AWSLC)
 
     /*
      * SSL_SESSION_get0_hostname() is only available in OpenSSL 1.1.1+,
diff --git a/src/stream/ngx_stream_ssl_module.c b/src/stream/ngx_stream_ssl_module.c
index 2f1b996246f..844aa90e746 100644
--- a/src/stream/ngx_stream_ssl_module.c
+++ b/src/stream/ngx_stream_ssl_module.c
@@ -592,7 +592,8 @@ ngx_stream_ssl_servername(ngx_ssl_conn_t *ssl_conn, int *ad, void *arg)
     sscf = ngx_stream_get_module_srv_conf(cscf->ctx, ngx_stream_ssl_module);
 
 #if (defined TLS1_3_VERSION                                                   \
-     && !defined LIBRESSL_VERSION_NUMBER && !defined OPENSSL_IS_BORINGSSL)
+     && !defined LIBRESSL_VERSION_NUMBER && !defined OPENSSL_IS_BORINGSSL     \
+     && !defined OPENSSL_IS_AWSLC)
 
     /*
      * SSL_SESSION_get0_hostname() is only available in OpenSSL 1.1.1+,